p57 Suppresses the Pluripotency and Proliferation of Mouse Embryonic Stem Cells by Positively Regulating p53 Activation

Embryonic stem cells (ESCs) are pluripotent stem cells that have indefinite self-renewal capacities under appropriate culture conditions in vitro.The Dresses pluripotency maintenance and proliferation of these cells are delicately governed by the concert effect of a complex transcriptional regulatory network.Herein, we discovered that p57Kip2 (p57)

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Experimental Analysis of Constrained Layer Damping Structures for Vibration Isolation in Lightweight Railway Vehicles

Rolling stock manufacturers face the challenge of manufacturing lightweight high-speed trains without deteriorating comfort.One of the difficulties is to mantain or increase structural stiffness and damping as the car bodies become lighter.Leaving aside active solutions, which are expensive and generally complex to implement, increasing structural

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Identification of potential small molecule allosteric modulator sites on IL-1R1 ectodomain using accelerated conformational sampling method.

The interleukin-1 receptor (IL-1R) is the founding member of the interleukin 1 receptor family which activates innate immune response by its binding to cytokines.Reports showed dysregulation of cytokine production leads to aberrant immune cells activation which contributes to auto-inflammatory disorders and diseases.Current therapeutic strategies f

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